Research

A student studies in the open spaces of the Genome Sciences Building at the University of North Carolina at Chapel Hill.

A student studies in the open spaces of the Genome Sciences Building at the University of North Carolina at Chapel Hill.

Overview

The lab studies how genes function within the three-dimensional context of the nucleus to control development and prevent disease. We combine genomic approaches (ChIP-Seq, ChIA-PET) and genome editing tools (CRISPR) to study the epigenetic mechanisms by which transcriptional regulatory elements control gene expression in embryonic stem cells.

Our current research efforts are divided into 3 main projects: