Gene regulation and chromosome structure during development and disease

Research in the lab investigates the link between genome organization and gene expression. We seek to understand how the looping of DNA impacts the expression of genes within a cell and how dynamic changes are brought about during normal development and disease processes. We use embryonic stem cells, cancer cells, and functional genomics approaches to study the mechanisms of transcriptional regulation and control of chromosome architecture.

Our lab is committed to the dual goals of uncovering the mechanisms of life and training scientists for successful careers. 

Embryonic stem cells grow as round colonies on top of a layer of long fibroblast supporting cells.

* Accepting applications for Postdoctoral Fellows and Graduate Students through UNC BBSP PhD Program.  To apply to the lab, send a cover letter and curriculum vitae to Jill Dowen